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目的探讨３２磷玻璃微球（３２ＰＧＭＳ）局部注射对裸鼠人肝癌移植瘤的治疗作用和超微结构影响。方法建立裸鼠人肝癌移植瘤模型后用３２ＰＧＭＳ进行治疗，取治疗后瘤组织用透射电镜观察。结果实验组瘤细胞大量坏死（３５％～７０％），残留的瘤细胞在分化上出现了一些差异，部分瘤细胞出现了高分化肝癌的形态特征；肿瘤间质见淋巴细胞浸润和纤维结缔组织增生，但无强烈的急性放射性炎反应；瘤体周围肌纤维和皮肤均无改变。对照组肿瘤示低分化肝癌，其中有少量死亡瘤细胞（４％）。结论３２ＰＧＭＳ抗肝癌作用明显，并有一定的免疫调节和促分化功能，对治疗区周围组织亦无损伤。
Objective To investigate the therapeutic effects and ultrastructural changes of 32PGMS(32PGMS) injection on human hepatocellular carcinoma xenografts in nude mice. Methods 32PGMS was used to treat human hepatocellular carcinoma xenografts in nude mice. The treated tissues were observed by transmission electron microscopy. Results The neoplastic cells in the experimental group were necrotic (35%～70%). The residual tumor cells showed some differences in differentiation. Some tumor cells showed morphological characteristics of well-differentiated liver cancer; interstitial lymphocytes infiltrated with lymphocytes and fibrous connective tissue. Hyperplasia, but no acute, acute radio-inflammatory reactions; no changes in muscle fibers and skin around the tumor. The control group of tumors showed poorly differentiated liver cancer, with a small number of dead tumor cells (4%). Conclusion 32PGMS has obvious anti-hepatocarcinoma effect, and has certain immunoregulatory and pro-differentiation functions. It also has no damage to the surrounding tissues of the treated area.