论文部分内容阅读
2007159 Acute kidney injury of systemic sclerosis: scleroderma renal crisis and crescentic glomerulonephritis. LIU Dongyan(刘冬妍), et al. Dept Nephrol, PUMC Hosp, CAMS & PUMC, Beijin 100730. Chin J Nephrol 2007;23(4):209-203. Objective To explore the clinicopathological characteristics of acute kidney injury (AKI) of systemic sclerosis (SSc). Methods A retrospective study was performed on 11 SSc patients with AKI. The clinical data were analyzed and the patients were divided into antineutrophil cytoplasmic antibodies (ANCA) negative group(n=9) and ANCA positive(n=2) group. Results In the ANCA negative group, 2 cases were without malignant hypertension, 1 was acute tubular necrosis(ATN) caused by herbs, 6 were scleroderma renal crisis(SRC), including 4 with renal biopsy, indicating hypertrophic arterial media, edema, thickened intima, onion-skin lesion in interlobular arteries and afferent arterioles, as well as ischemic lesion in glomeruli. In the MPO-ANCA positive group, 1 was crescentic glomerulonephritis. Malignant hypertension was not noticed. All patients were given steroid, 8 of them received CTX in addition. Nine patients received dialysis, and 8 cases progressed to permanent hemodialysis. Six cases with SRC were given high dose ACEI and / or ARB. Six patients resulted in early death. Conclusion Scleroderma renal crisis and ANCA associated vasculitis may cause AKI in SSc patients. Patients with positive ANCA differ from those with negative ANCA in terms of clinical manifestation, pathology and treatment. Survival and prognosis of SSc patient were bad. High dose corticosteroids increases the risk of scleroderma renal crisis, so it is thereby recommended that the dose above 15 rog/day should be avoided if possible.
2007 159 Acute kidney injury of systemic sclerosis: scleroderma renal crisis and crescentic glomerulonephritis. LIU Dongyan, et al. Dept Nephrol, PUMC Hosp, CAMS & PUMC, Beijin 100730. Chin J Nephrol 2007; 23 (4): 209-203 Objective To explore the clinicopathological characteristics of acute kidney injury (AKI) of systemic sclerosis (SSc). Methods A retrospective study was performed on 11 SSc patients with AKI. The clinical data were analyzed and the patients were divided into antineutrophil cytoplasmic antibodies (ANCA Results of the ANCA negative group, 2 cases were without malignant hypertension, 1 was acute tubular necrosis (ATN) caused by herbs, 6 were scleroderma renal crisis (n = 9) SRC), including 4 with renal biopsy, indicating hypertrophic arterial media, edema, thickened intima, onion-skin lesion in interlobular arteries and afferent arterioles, as well as ischemic lesion in glomeruli. In the MPO-ANCA positive group, 1 wa All patients were given steroid, 8 of them received CTX in addition. Nine patients received dialysis, and 8 cases progressed to permanent hemodialysis. Six cases with SRC were given high dose of ACEI and / or ARB Six patients resulted in early death. Conclusion Scleroderma renal crisis and ANCA associated vasculitis may result in AKI in SSc patients. Patients with positive ANCA differ from those with negative ANCA in terms of clinical manifestation, pathology and treatment. Survival and prognosis of SSc patient were bad. High dose corticosteroids increases the risk of scleroderma renal crisis, so it is therefore recommended that the dose above 15 rog / day should be avoided if possible.