雷洛昔芬和泰莫西芬是人工合成雌激素受体调节剂,具有与雌激素受体的高亲和力,并且拥有在不同的靶组织可分别表现为雌激素激动剂和拮抗剂的特性,因此又被称为选择性雌激素受体调节剂,这类药物的出现为患绝经后综合征的女性病人提供了新的用药选择。着重综述雷洛昔芬和泰莫西芬等具代表性的选择性雌激素受体调节剂在绝经后女性中的应用研究进展。 Raloxifene and tamoxifen are synthetic estrogen receptor modulators with high affinity for estrogen receptors and possess the properties of being estrogen agonists and antagonists, respectively, in different target tissues, It is also known as a selective estrogen receptor modulator, the emergence of such drugs for the treatment of women with postmenopausal syndrome provides a new choice of medication. The research progress of the application of representative selective estrogen receptor modulators such as raloxifene and tamoxifen in postmenopausal women is reviewed.