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Several simple, fast and practical protocols have been developed to synthesize internal or terminal propar-gylamines and chalcones via A3-coupling reaction of aldehydes, amines, and alkynes catalyzed by an eas-ily available catalyst Ag2CO3 under solvent-free condition. The reaction proceeded smoothly to deliver various products in good-to-excellent yields with good functional group tolerance. Gram-scale prepa-ration, bioactive molecule synthesis and asymmetric substrates have been demonstrated. Furthermore, plausible mechanisms for the synthesis of different products have been proposed.