论文部分内容阅读
目的:观察中西医结合治疗非酒精性脂肪性肝病(NAFLD)痰瘀互结证的临床疗效。方法:收集96例NAFLD病例,随机分为观察组和对照组各48例,2组均给予非药物康复治疗,对照组采用多烯磷脂酰胆碱胶囊和还原型谷胱甘肽片治疗,观察组在对照组治疗基础上给予膈下逐瘀汤联合二陈汤治疗。2组患者均治疗12周。检测2组患者治疗前后谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆固醇(TC)和甘油三酯(TG)水平;比较2组的中医证候积分和临床疗效。结果:总有效率观察组为95.83%,对照组为79.17%,2组比较,差异有统计学意义(P<0.05)。治疗后6周,观察组ALT和AST水平均较治疗前下降(P<0.01),而对照组2项指标值下降不明显;观察组ALT和AST水平均低于对照组(P<0.01)。治疗后12周,2组ALT和AST水平均较治疗前下降(P<0.01),观察组ALT和AST水平均低于对照组(P<0.01)。治疗后,2组中医证候积分、TG和TC均较治疗前下降(P<0.01);观察组中医证候积分、TG和TC均低于对照组(P<0.01)。结论:在常规西医治疗基础上以膈下逐瘀汤联合二陈汤治疗NAFLD痰瘀互结证,可明显改善患者的肝功能和中医证候,促进血脂好转,其疗效优于单纯西医治疗。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of non-alcoholic fatty liver disease (NAFLD). Methods: Ninety-six cases of NAFLD were collected and randomly divided into observation group and control group, 48 cases each. Both groups were given non-drug rehabilitation treatment. The control group was treated with polyene phosphatidylcholine capsule and reduced glutathione tablets. Group in the control group on the basis of treatment given Gelxia Zhuyu Decoction combined with two Chen Tang treatment. Two groups of patients were treated for 12 weeks. The levels of ALT, AST, TC and triglyceride were measured before and after treatment. The TCM syndrome scores and clinical efficacy were compared between the two groups. Results: The total effective rate was 95.83% in the observation group and 79.17% in the control group. There was significant difference between the two groups (P <0.05). At 6 weeks after treatment, the levels of ALT and AST in the observation group decreased compared with those before treatment (P <0.01), while those in the control group did not decrease significantly. The levels of ALT and AST in the observation group were lower than those in the control group (P <0.01). Twelve weeks after treatment, the levels of ALT and AST in both groups were significantly lower than those before treatment (P <0.01). The levels of ALT and AST in the two groups were lower than those in the control group (P <0.01). After treatment, the scores of TCM syndromes, TG and TC decreased in both groups (P <0.01). The scores of TCM syndrome, TG and TC in the observation group were lower than those in the control group (P <0.01). Conclusion: The treatment of NAFLD phlegm, blood stasis and cross-over syndrome with Ge Xia Zhu Yu Decoction combined with Erchen Decoction on the basis of routine western medicine can significantly improve the liver function and TCM syndrome of patients and promote the improvement of blood lipid. The curative effect is superior to that of Western medicine alone.