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测定精索静脉曲张、腹股沟斜疝患者和正常人不同静脉血中五羟色胺（５－ＨＴ）含量，同时观察曲张者睾丸生殖病理和超微结构变化。结果表明：曲张者精索内静脉血中５－ＨＴ浓度明显增高，血清中５－ＨＴ浓度和精子计数、精子活率之间呈负相关。曲张者睾丸组织学以Ⅱ级病理改变为主，生精细胞胞浆内线粒体变化十分明显，提示：５－ＨＴ对睾丸生精功能的毒性作用是精索静脉曲张不育的重要原因之一，术中５－ＨＴ含量测定结合备睾丸活检有助于对预后作出评估。
The contents of 5-hydroxytryptamine (5-HT) in varicocele, inguinal hernia and normal human venous blood samples were measured. The reproductive pathology and ultrastructure of varicocele were also observed. The results showed that the concentration of 5-HT in the varicocele was significantly increased, and there was a negative correlation between serum 5-HT concentration and sperm count and sperm motility. Tissue testis histology to grade Ⅱ pathological changes, mainly in the cytoplasm of spermatogenic cells changes in mitochondria is very obvious, suggesting: 5-HT on the testicular spermatogenesis is one of the important causes of varicocele infertility, Intraoperative 5-HT combined with testis biopsy can help assess the prognosis.