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目的 探讨慢性心力衰竭患者血清细胞凋亡抑制物可溶性Fas(sFas)及可溶性肿瘤坏死因子受体Ⅰ (sTNFR Ⅰ )的水平。方法 6 2例慢性心力衰竭患者 ,按心功能分级 (NYHA)分为 3组 :Ⅱ级组 2 0例 ,Ⅲ级组 2 0例 ,Ⅳ级组 2 2例 ;另设 15例健康人作对照。血清sFas、及sTNFR Ⅰ含量测定采用酶联免疫吸附法。结果 慢性心力衰竭患者血清sFas及sTNFR Ⅰ显著高于健康对照组 (P <0 .0 1) ,慢性心力衰竭患者心功能分级组间血清sFas及sTNFR Ⅰ含量也有显著差异 (P <0 .0 1)。结论 慢性心力衰竭患者血清sFas及sTNFR Ⅰ含量的变化可能参与慢性心力衰竭的致病机制 ,它们的含量变化对慢性心力衰竭时心肌细胞凋亡的影响可能是其机制之一。
Objective To investigate the serum levels of soluble Fas (sFas) and soluble tumor necrosis factor receptor Ⅰ (sTNFR Ⅰ) in patients with chronic heart failure. Methods Sixty patients with chronic heart failure were divided into 3 groups according to the cardiac function classification (NYHA): 20 cases in grade Ⅱ, 20 cases in grade Ⅲ and 22 cases in grade Ⅳ, and 15 healthy people as control . Serum sFas and sTNFR Ⅰ levels were measured by enzyme-linked immunosorbent assay. Results Serum levels of sFas and sTNFR Ⅰ in patients with chronic heart failure were significantly higher than those in healthy controls (P <0.01). Serum levels of sFas and sTNFR Ⅰ were also significantly different between patients with chronic heart failure and those with chronic heart failure (P <0.01) ). Conclusions The changes of serum sFas and sTNFR Ⅰ levels in patients with chronic heart failure may be involved in the pathogenesis of chronic heart failure. The effects of their changes on the apoptosis of myocardial cells in chronic heart failure may be one of its mechanisms.