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用６４只离体大鼠子宫平滑肌（ＵＳＭ），探讨油茶皂甙（ＳＱＳ）对ＵＳＭ作用。结果：（１）当加入ＳＱＳ溶液５～１０μｇ／ｍｌ时，对缩宫素（Ｏｘｙ）及高Ｋ＋去极化后所引起的ＵＳＭ收缩均有明显的抑制作用，但可被增加浴液中的Ｃａ２＋浓度所对抗；（２）累积量－效曲线表明，ＳＱＳ与ＣａＣｌ２呈非竞争性拮抗；（３）ＳＱＳ尚对Ｏｘｙ所致ＵＳＭ的依细胞内Ｃａ２＋以及依细胞外Ｃａ２＋的收缩反应均有抑制作用。结果表明ＳＱＳ有抗Ｃａ２＋作用，从而能抑制ＵＳＭ的收缩。这在基础理论和临床实践上均有较大的意义。
Sixty-four isolated rat uterine smooth muscle cells (USM) were used to investigate the effect of saponin (SQS) on USM. Results: (1) When 5 ~ 10μg / ml of SQS solution was added, the inhibitory effect on the contraction of USM induced by oxytocin and high K + depolarization was obviously inhibited. However, (2) The cumulant-efficiency curves showed that SQS was noncompetitively antagonized with CaCl2; (3) SQS inhibited the intracellular Ca2 + and the extracellular Ca2 + contractile response of Oxygen-induced USM effect. The results show that SQS anti-Ca2 + role, which can inhibit USM contraction. This has great significance in the basic theory and clinical practice.