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大多数恶性外周神经鞘膜瘤(MPNST)表现为NF1、CDKN2A及多梳抑制复合体2组成基因——胚胎外胚层发育基因(EED)和Zeste 12抑制基因(SUZ12)的共同缺失。EDD和SUZ12的突变导致组蛋白H3第27号位赖氨酸上三甲基化(H3K27me3)无法进行,导致多梳抑制复合体2抑制性同源盒主调控因子转录活性异常。因此,作者探讨抗H3K27me3单克隆抗体C36B11作为MPNST免疫组化标志
Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit the common deletion of the NF1, CDKN2A and multicombination inhibitory complex 2 genes (EED) and the Zeste 12 suppressor gene (SUZ12). Mutations in EDD and SUZ12 resulted in inability of trimethylation of lysine at position 27 of histone H3 (H3K27me3), resulting in multiple comb inhibition of complex 2 inhibitory homeobox transcriptional regulators transcriptional activity abnormalities. Therefore, the authors investigated the anti-H3K27me3 monoclonal antibody C36B11 as an immunohistochemical marker of MPNST