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目的：探讨Ａ型肉毒毒素局部注射治疗面肌痉挛、各型头颈肌张力障碍的临床疗效和安全性。方法：采用Ａ型肉毒毒素局部多点注射痉挛肌肉，治疗前后对照。结果：治疗面肌痉挛２５０例（１０２８轮次），有效率１００％，作用持续１６ｗｋ±ｓ４ｗｋ；睑痉挛７８例（２６０轮次），有效率９３．９％，作用持续１５ｗｋ±４ｗｋ；口颌肌痉挛５３例（１８１轮次），有效率８５．１％，作用持续１４ｗｋ±４ｗｋ；痉挛性斜颈２８例（７９轮次），有效率８１％，作用持续１４ｗｋ±４ｗｋ。副作用轻微、可逆。结论：该疗法安全、有效，可作为面肌痉挛及各型头颈部肌张力障碍的首选治疗。
Objective: To investigate the clinical efficacy and safety of local injection of botulinum toxin type A in the treatment of hemifacial spasm and dizziness of head and neck. Methods: A botulinum toxin type A local multi-injection spasm muscle, before and after treatment control. Results: In the treatment of hemifacial spasm in 250 cases (1028 rounds), the effective rate was 100% and the effect continued for 16 weeks ± s4wk. Blepharospasm was performed in 78 cases (260 cycles) with an effective rate of 93.9% and the effect lasted 15 weeks ± 4 weeks. 53 cases (181 rounds) of muscle spasm, the effective rate was 85.1%, the effect lasts 14wk ± 4wk; spastic torticollis 28 cases (79 rounds), the effective rate of 81%, the effect lasts 14wk ± 4wk. Side effects are mild and reversible. Conclusion: The therapy is safe and effective and can be used as the first choice for treatment of hemifacial spasm and head and neck dystonia.