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肿瘤组织比正常组织对周围环境变化更为敏感，直流电激活血管——间质闭合电路，改变了肿瘤的微循环系统，使肿瘤组织产生多种病理效应，细胞膜崩溃，线粒体消失，核蛋白凝固，最终达到肿瘤的坏死、消退，这就是电化学治疗恶性肿瘤的机理。我院胸心外科１９９０年６月—１９９４年１月应用自己制备的电极电化学治疗食管癌病人７例，取得显著的临床效果，经三年多的临床观察，肿瘤消失率为１４．２８％，缩小率为７１．４２％，总有效率为１００％。带瘤生存期延长，生活质量提高，特别是对中晚期食管癌病例证实是一种新的安全，有效的治疗方法。
Tumor tissue is more sensitive to changes in the surrounding environment than normal tissue. Direct current activates the vascular-interstitial closed circuit, which changes the tumor’s microcirculation system, causing tumor tissue to produce a variety of pathological effects, cell membrane breakdown, mitochondrial disappearance, and nuclear protein coagulation. Ultimately, necrosis and regression of the tumor are achieved, which is the mechanism of electrochemical treatment of malignant tumors. The thoracic surgery in our hospital from June 1990 to January 1994 applied electrochemistry of electrodes prepared by ourselves to treat 7 patients with esophageal cancer and achieved remarkable clinical results. After more than three years of clinical observation, the tumor disappearance rate was 14.28%. The reduction rate was 71.42% and the total effective rate was 100%. The extended tumor survival time and improved quality of life, especially for advanced esophageal cancer, are indeed a new safe and effective treatment.