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目的 观察早期伍用纳洛酮干预治疗新生儿缺氧缺血性脑病 (HIE)的疗效。方法 4 4例新生儿缺氧缺血性脑病患儿随机分为两组 ,治疗组在常规治疗基础上伍用纳洛酮 0 1mg/kg ,静推一次后再改为0 0 5mg·kg-1·d-1+10 %GS 4 0～ 6 0ml静脉点滴 (持续 4～ 6h) ,治疗 1周。分别观察患儿临床症状、体征变化 ,并行NBNA评分。结果 经伍用纳洛酮早期干预治疗后临床症状评分明显减低 ,NBNA评分高于对照组 ,差异有显著意义 (P <0 0 5 )。结论 纳洛酮早期干预治疗HIE能起到更好的脑保护作用 ,降低患儿致残率 ,提高生存质量。
Objective To observe the effect of early use of naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods4 4 neonates with hypoxic-ischemic encephalopathy were randomly divided into two groups. The treatment group was treated with naloxone 0 1 mg / kg on the basis of conventional treatment, and then was re-treated with 0 5 mg · kg- 1 · d-1 + 10% GS 4 0 ~ 60ml intravenous drip (lasting 4 ~ 6h) for 1 week. Clinical symptoms and signs in children were observed, and NBNA score was evaluated. Results After treatment with naloxone, the score of clinical symptoms was significantly lower, and the NBNA score was higher than that of the control group (P <0.05). Conclusion Naloxone early intervention treatment of HIE can play a better role in brain protection, reduce the rate of disability in children and improve the quality of life.