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1990年12月以来,我们对186名反复呼吸道感染(RAI)小儿进行了血清维生素A(VA)水平观察,其中正常58例(31.2％ ),不足74例(39.8％ ),缺乏44例(23.7％),严重缺乏10例(5.4％ ),总平均值为0.92±0.38 μmol/L。同时测定28例无感染小儿,其血清VA属正常范围12例(42.9％),不足14例(50％),缺乏2例(7.1％ ),严重缺乏为0,总平均值为1.07±0.32μmol/L,二者相比P<0.05,有显著差异。对其中143例进行分组观察,实验组87例,每年口服VA2次(每次按1～6岁15 ×10~4 IU,6岁以上20 ×10~4 IU,顿服,间隔4～6个月);对照组56例,不给VA。经1年观察,两组在发病次数、天数和疾病严重度方面均有明显差异,实验组较对照组发病少、短、轻。同时对174例RAI小儿测定了免疫球蛋白(Ig),结果以IgA升高(46％),IgG (42.5％)及IgM (21.3％)降低者居多(1例可同时有2或3项改变),实验组及对照组血清IgA无差异,8～10周后重复再测,两组血清IgA数值下降者居多,且实验组与对照组相比有非常显著差异(P=0.000 1 ),实验组数值高于对照组。
Serum vitamin A (VA) levels were observed in 186 children with recurrent respiratory tract infections (RAI) since December 1990, with 58 (31.2%) normal, less than 74 (39.8%), and 44 (23.7) %), A serious lack of 10 cases (5.4%), with a mean of 0.92 ± 0.38 μmol / L. Serum VA was detected in 12 cases (42.9%), less than 14 cases (50%), lacking in 2 cases (7.1%), severe deficient in 0, with a mean of 1.07 ± 0.32 μmol / L, both compared P <0.05, there are significant differences. One hundred and forty-three patients were divided into groups and observed. The experimental group was treated with oral VA2 twice a year (15 × 10 ~ 4 IU for 1 ~ 6 years old, 20 × 10 ~ 4 IU for 6 years old, Month); control group of 56 patients, not to VA. After one year of observation, there were significant differences between the two groups in the frequency of onset, the number of days and the severity of the disease. The experimental group had less incidence, shortness and lightness than the control group. At the same time, immunoglobulin (Ig) was measured in 174 children with RAI. The results showed that IgA increased (46%), IgG (42.5%) and IgM (21.3% ). There was no difference in serum IgA between the experimental group and the control group. After 8 to 10 weeks, the serum IgA levels were mostly decreased. There was a significant difference between the experimental group and the control group (P = 0.000 1) Group values higher than the control group.