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目的:观察珍佛散治疗癌性胸水(carcinoma thorax aqueous)的疗效及毒副作用。方法:确诊为恶性胸腔积液患者82例,随机分为两组。治疗组(n=41)口服中药制剂珍佛散20g,2次/d,连续服用21d;对照组(n=41)胸腔注入顺铂40mg/m2。结果:治疗组CR数为30例,PR为8例,NR为3例,总有效38例;对照组CR为12例,PR为10例,总有效22例。治疗组有效率为92.7%,对照组有效率为53.66%,治疗组比对照组疗效显著(P<0.05)。治疗组发生恶心、呕吐胃肠副反应7例(17.1%)比对照组16例(39.0%)少(P<0.05),并无血细胞下降副反应。结论:珍佛散是一种治疗恶性胸水安全而有效的中药制剂。
Objective: To observe the curative effect and toxicity of Zhenfasan on carcinoma thorax aqueous. Methods: 82 patients diagnosed as malignant pleural effusion were randomly divided into two groups. The treatment group (n = 41) was orally administered Zhenfasan 20g twice a day for 21 days, while the control group (n = 41) was injected with 40mg / m2 cisplatin. Results: CR was 30 in the treatment group, 8 in the PR group, 3 in the NR group and 38 in the control group. CR was 12 in the control group, 10 in the PR group and 22 in the total. The effective rate was 92.7% in the treatment group and 53.66% in the control group, and the curative effect in the treatment group was significantly higher than that in the control group (P <0.05). Seven patients (17.1%) had nausea and vomiting and gastrointestinal side effects and 16 patients (39.0%) had less nausea and vomiting (P <0.05) than those in the control group. There was no side effect of blood cell descending. Conclusion: Zhenfo San is a safe and effective treatment of malignant pleural effusion of traditional Chinese medicine.