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作者自1980年5月到1985年10月曾对62例食管鳞癌病人常规外照射后又进行了高剂量率的腔内照射,其中有12例生存期超过了两年。作者见到,12例中的4例,在照射后13～21个月时发生了严重狭窄。3例发生在食管下段,1例在中段。12例中11例有良性食管溃疡,为长环形或线形,4例最后发展成食管狭窄。作者指出,肿瘤的长度和腔内照射剂量的大小和狭窄的严重程度有关。放疗后损伤开始修复,较长的肿瘤病变区需要较长时间的修复和产生较长区域的纤维化,引起较严重的狭窄。较高剂量的腔内照射引起较严重的组织学变化,粘膜下
From May 1980 to October 1985, the authors conducted high-dose-rate intracavitary irradiation on 62 patients with esophageal squamous cell carcinoma after routine external exposure, and 12 of them survived for more than two years. The authors saw that 4 out of 12 cases had severe stenosis at 13-21 months after irradiation. Three cases occurred in the lower esophagus and one in the middle. Eleven of the 12 cases had benign esophageal ulcers, which were either toroidal or linear in shape. Four cases eventually developed esophageal strictures. The authors pointed out that the length of the tumor and the size of the irradiation dose in the cavity are related to the severity of the stenosis. The injury begins to repair after radiotherapy, longer lesions of the tumor need a longer time to repair and produce a longer area of fibrosis, causing more severe stenosis. Higher doses of intraluminal irradiation cause more severe histological changes, submucosal