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目的:探讨液基细胞学联合人乳头瘤病毒检测宫颈癌筛查中的应用及其意义。方法:随机选取宫颈癌筛查和宫颈癌癌前病变的患者910例,将其分为对照组和观察组,每组患者455例。首先对两组通过液基超薄细胞学检查进行阳性筛查,然后,在此基础上对观察组进行液基超薄细胞学,通过液基细胞学联合人乳头瘤病毒检测进行阳性筛查。结果:观察组经液基超薄细胞学与高危型人乳头瘤病毒检查筛查出阳性患者30例,经病理检查确定的阳性患者25人,临床诊断符合率达83.3%,对照组筛查检验出阳性患者58例,经病理检查确定阳性患者为34例,临床诊断符合率为58.6%,两组阳性临床诊断符合率比较差异具有统计学意义P<0.01。结论:液基细胞学检查与人乳头瘤病毒检测在宫颈癌筛查,两种方式相互补充,联合应用两种检测方法能够提高临床诊断符合率,使漏诊率得到降低,具有较高的早期筛查宫颈癌的应用价值,利于癌症的早发现、早治疗,临床意义显著。
Objective: To explore the application of liquid-based cytology combined with human papillomavirus in the screening of cervical cancer and its significance. Methods: A total of 910 patients with cervical cancer screening and cervical precancerous lesions were randomly selected and divided into control group and observation group with 455 patients in each group. First, two groups were screened by liquid-based ultrathin cytology. Then, based on this, the superficial cytology was observed in the observation group and positive screening by liquid-based cytology combined with human papillomavirus test. Results: In the observation group, 30 cases of positive patients were screened by liquid-based ultra-thin cytology and high-risk human papillomavirus test, and 25 cases were positive by pathological examination. The coincidence rate of clinical diagnosis was 83.3% Fifty-eight positive cases were positive, of which 34 were positive by pathology. The coincidence rate of clinical diagnosis was 58.6%. There was significant difference between the two groups in the positive rate of clinical diagnosis (P <0.01). Conclusion: Liquid-based cytology and human papillomavirus (HPV) detection in cervical cancer screening, two ways complement each other, the combination of two detection methods can improve the clinical diagnosis of coincidence rate, so that the rate of missed diagnosis, with a high early screening Check the value of cervical cancer, which will help early detection of cancer, early treatment, clinical significance.