多伦多大学医学院附属医院的临床药理研究在加拿大居领先地位。其主要研究内容如下: 一、关于药物代谢动力学的研究不仅对原形药而且对其代谢产物进行研究,正在观察茶硷的三种代谢产物(3-methylxanthine、theobromine及8-chlorotheophlline)的药代动力学。对茶硷本身的药代动力学研究证明,男性的清除率比女性高22～31%。 Clinical Pharmacology Research at the University of Toronto Medical School Hospital is the leading place in Canada. The main contents are as follows: First, the study on pharmacokinetics not only on the prototype drugs but also on their metabolites, is studying the theophylline three metabolites (3-methylxanthine, theobromine and 8-chlorotheophlline) on behalf of the drug dynamics. Pharmacokinetic studies of theophylline itself have shown that men have a clearance of 22-31% higher than that of women.