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【目的】观察参芪扶正注射液对联合放、化疗肿瘤患者心肌损伤的保护作用。【方法】将68例行联合放、化疗患者随机分为治疗组和对照组各34例。对照组单纯用放、化疗方案,治疗组在进行放、化疗的前3 d开始静脉滴注参芪扶正注射液250 mL,每日1次,疗程与放、化疗同期结束。检测治疗后6周、12周的超声心动图左、右心室Tei指数。【结果】联合放、化疗6周、12周后,治疗组的左、右心室等容舒张时间(IRT)、等容舒张指数(IRT/ET)及Tei指数均显著低于对照组,差异均有统计学意义(P<0.05),而左、右心室等容收缩时间(ICT)及左、右心室收缩指数(ICT/ET)两组间比较差异无统计学意义(P>0.05)。【结论】参芪扶正注射液在肿瘤患者联合放、化疗过程中对心肌有保护作用。
【Objective】 To observe the protective effect of Shenqi Fuzheng injection on myocardium injury in patients with combined radiotherapy and chemotherapy. 【Methods】 Sixty-eight patients with combined radiotherapy and chemotherapy were randomly divided into treatment group (34 cases) and control group (34 cases). The control group was treated with radiotherapy and chemotherapy alone. The treatment group began intravenous infusion of Shenqi Fuzheng Injection 250 mL three times daily for the first 3 days of radiotherapy and chemotherapy. The treatment group was given the same period of chemotherapy and radiotherapy. The left and right ventricular Tei index were measured at 6 weeks and 12 weeks after echocardiography. 【Results】 The left and right ventricular isovolumic relaxation time (IRT), isovolumic relaxation index (IRT / ET) and Tei index of the treated group were significantly lower than those of the control group after 6 and 12 weeks of radiotherapy and chemotherapy (P <0.05). There was no significant difference between left and right ventricular systolic time (ICT) and right and left ventricular systolic index (ICT / ET) between the two groups (P> 0.05). 【Conclusion】 Shenqi Fuzheng injection in combination with chemotherapy in patients with cancer, chemotherapy has a protective effect on the myocardium.