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目的观察左炔诺孕酮宫内缓释系统对子宫腺肌症的治疗效果。方法选择由子宫腺肌症导致的中、重度痛经患者40例,在月经期的第1~5天放置LNG-IUS。在放置前及放置后3、6、12个月时分别进行VAS痛经评分,PBAC经量评分,B超测定子宫体积和子宫内膜厚度,并测量血清CA125、血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)水平。结果放置LNG-IUS后,40例痛经患者的VAS评分、PBAC评分显著下降,差异具有统计学意义(P<0.03);置环后子宫内膜厚度、血清CA125均有所下降,其差异具有统计学意义(P<0.05);而E2、FSH和LH水平则未出现明显变化。结论 LNG-IUS是治疗子宫腺肌症所致中、重度痛经的安全且有效的方法。
Objective To observe the therapeutic effect of levonorgestrel intrauterine system on adenomyosis. Methods 40 cases of moderate and severe dysmenorrhea caused by adenomyosis were selected, and LNG-IUS was placed on the 1st to 5th day of menstruation. VAS dysmenorrhea score, PBAC volume score, B-ultrasound, uterine volume and endometrial thickness were measured before and 3, 6, and 12 months after placement. Serum CA125, serum estradiol (E2) Stimulating hormone (FSH), luteinizing hormone (LH) levels. Results After placement of LNG-IUS, the VAS score and PBAC score of 40 dysmenorrhea patients decreased significantly (P <0.03). The thickness of endometrium and serum CA125 decreased after the placement of LNG-IUS, and the difference was statistically significant (P <0.05), while E2, FSH and LH levels did not change significantly. Conclusion LNG-IUS is a safe and effective method for the treatment of moderate and severe dysmenorrhea caused by adenomyosis.