肝纤维化是日本血吸虫病发展至后期的肝脏组织病理学改变,是致血吸虫病严重并发症的主要原因和病理学基础。近年来,国内外通过动物实验,证明早期使用吡喹酮抗血吸虫治疗可抑制肝纤维化的发生,并可使轻度肝纤维化逆转。但对较明显的肝纤维化,由于尚未完全了解的免疫病理机制,临 Hepatic fibrosis is a pathological change of liver histopathology from the development of schistosomiasis japonica to the late stage, which is the main cause and pathological basis of severe complications of schistosomiasis. In recent years, domestic and foreign animal experiments show that the early use of praziquantel anti-schistosome treatment can inhibit the occurrence of liver fibrosis, and mild liver fibrosis can be reversed. However, the more obvious liver fibrosis, due to not yet fully understand the immune pathology, Pro