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目的评估16 y以下儿童使用阿奇霉素安全性,为儿童使用阿奇霉素提供参考。方法前瞻性调查2008-05-01~2010-08-30中山地区5家医疗机构16 y以下患者使用阿奇霉素后出现药品不良反应的情况。结果对19 831例次16 y以下使用阿奇霉素的患者进行了跟踪监测,其不良反应发生率为1.39%(276例),其中注射给药占72.83%,71.02%发生在用药后1 h以内,严重ADR只有3例,联用品种越多,ADR发生率越高。结论 16 y以下儿童使用阿奇霉素不良反应较低,使用比较安全。
Objective To evaluate the safety of azithromycin in children younger than 16 years and provide reference for azithromycin in children. Methods Prospective investigation 2008-05-01 ~ 2010-08-30 Adverse drug reactions occurred after azithromycin was administered to patients under 16 years in five medical institutions in Zhongshan District. Results A total of 19 831 patients under azithromycin 16 y were followed up. The incidence rate of adverse reactions was 1.39% (276 cases), of which 72.83% were injected and 71.02% occurred within 1 h after treatment, ADR only 3 cases, the more joint species, the higher the incidence of ADR. Conclusions Azithromycin is less harmful to children under 16 years of age and is safer to use.