论文部分内容阅读
长链非编码RNA(1ong non-coding RNA,lnc RNA)是一组长度超过200 bp、缺少特异开放阅读框、不具备完整蛋白编码功能的RNA,其在表观遗传学调控以及转录和转录后调控等方面发挥重要作用。目前,在乳腺癌和肝癌中对Lnc RNA的研究颇多,而对胃癌中Lnc RNA的报道却刚刚兴起。近几年越来越多的研究发现,在胃癌中有很多特异表达的Lnc RNA与胃癌的发生、发展、侵袭、转移密切相关。本文结合国内外最新研究就lnc RNA在胃癌中的研究进展作一简要综述,主要介绍了Lnc RNA在肿瘤研究中的最新发现,尤其是其与胃癌发生发展的密切联系,旨在为胃癌的诊断和治疗提供新思路。
Long-chain non-coding RNA (lnc RNA) is a group of RNA that has a length of more than 200 bp and lacks a specific open reading frame and does not have the function of complete protein coding. After being epigenetically regulated and transcribed and transcribed Regulation and other aspects play an important role. Currently, there are many studies on Lnc RNA in breast cancer and liver cancer, but the report on Lnc RNA in gastric cancer has just been started. In recent years, more and more studies have found that there are many specific expression of Lnc RNA in gastric cancer is closely related to the occurrence, development, invasion and metastasis of gastric cancer. This review summarizes the progress of lnc RNA in gastric cancer based on the latest research at home and abroad, and introduces the latest findings of Lnc RNA in tumor research, especially its close relationship with the development of gastric cancer, aimed at the diagnosis of gastric cancer And treatment to provide new ideas.