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目的观察氟伐他汀钠和马来酸罗格列酮联合使用对2型糖尿病患者脉搏波传导速度的影响。方法选取80例2型糖尿病患者,40例血脂正常者为对照组,40例血脂异常者为治疗组,在原有治疗的基础上全部加用马来酸罗格列酮,血脂异常者同时加用氟伐他汀钠,加用前及治疗6个月后,分别检测空腹血糖(FPG)、糖化血红蛋白(HbA1 c)、总胆固醇(TC)、甘油三酯(TG)、臂-踝脉搏波传导速度(baPWV),并比较各指标的变化。结果氟伐他汀联合马来酸罗格列酮治疗6个月后,患者FPG、HbA1 c、TC、TG、baPWV均下降(P<0.05)。结论联合使用氟伐他汀和马来酸罗格列酮能明显降低2型糖尿病患者的baPWV,改善动脉硬化。
Objective To observe the effect of fluvastatin sodium combined with rosiglitazone maleate on pulse wave velocity in type 2 diabetic patients. Methods 80 patients with type 2 diabetes mellitus, 40 patients with normal blood lipids as control group, 40 patients with dyslipidemia as the treatment group, all of the original treatment based on the addition of rosiglitazone maleate, dyslipidemia were added Fluvastatin sodium was taken before and 6 months after treatment. Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), brachial ankle pulse wave velocity (baPWV), and compare the changes of each index. Results Fluvastatin combined with rosiglitazone maleate 6 months after treatment, patients with FPG, HbA1 c, TC, TG, baPWV were decreased (P <0.05). Conclusions Combination of fluvastatin and rosiglitazone maleate can significantly reduce baPWV and improve atherosclerosis in type 2 diabetic patients.