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目的：观察异丙酚对安氟醚最低肺泡有效浓度（ＭＡＣ）及手术切皮无应激反应的ＭＡＣ（ＭＡＣ－ＢＡＲ）的影响。方法：ＡＳＡＩ－Ⅱ级择期手术病人３０例，随机分为两组，以手术切皮为疼痛刺激方法。异丙酚用３ｍｇｋｇ－１的诱导剂量加５３．８μｇｋｇ－１ｍｉｎ－１连续输注。结果：测得安氟醚ＭＡＣ为１．６０９Ｖｏｌ％，ＭＡＣ－ＢＡＲ为１．７３６Ｖｏｌ％，与经典值相对照，异丙酚对安氟醚ＭＡＣ没有明显影响，但能降低ＭＡＣ－ＢＡＲ３５．５％。结论：异丙酚镇痛作用很弱或没有镇痛作用，异丙酚应用后不必用高浓度吸入麻醉药即可阻断循环与内分泌反应，用ＭＡＣ－ＢＡＲ作麻醉强度指标，能显著减少或基本消除手术中的心血管及神经内分泌应激反应。
Objective: To investigate the effect of propofol on the minimum alveolar concentration (MAC) and MAC-BAR in surgical incision. Methods: Thirty ASAI-Ⅱ patients undergoing elective surgery were randomly divided into two groups. Surgical skin incision was used as pain stimulus. Propofol was continuously infused with an induction dose of 3 mg kg-1 plus 53.8 μg kg-1 min-1. Results: The enflurane MAC was 1.609Vol% and the MAC-BAR was 1.736Vol%. Compared with the classical value, propofol did not affect the enflurane MAC, but could reduce the MAC-BAR 35.5% . CONCLUSION: The analgesic effect of propofol is weak or no analgesic effect. Propofol can block the circulatory and endocrine reactions without inhalation of high concentrations of anesthetics. The use of MAC-BAR as anesthetic strength index can significantly reduce or The basic elimination of cardiovascular and neuroendocrine stress during surgery.