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目的观察龙血竭总酚滴丸对麻醉犬动脉血压、脑血流量及脑血管阻力的影响。方法将36只犬均分为龙血竭总酚滴丸组(大、中、小剂量)、原料药组、阳性对照药(血塞通片)组及空白对照组。采用电磁流量计测定给药前、后各时间段的血压及椎动脉、颈内动脉的血流量,计算脑血流量及脑血管阻力。结果龙血竭总酚滴丸能明显增加麻醉犬的脑血流量(P<0.05),并且中剂量能有效降低脑血管阻力(P<0.05、P<0.01)。结论龙血竭总酚滴丸对维持脑组织血液的灌流量有明显作用。
Objective To observe the effects of Longdexu Total Phenolic Pills on the arterial blood pressure, cerebral blood flow and cerebral vascular resistance in anesthetized dogs. Methods Thirty-six dogs were divided into three groups: the control group (group), the drug group, the positive control drug (Xuesaitong Tablet) and the blank control group. The blood pressure before and after administration and the blood flow of vertebral artery and internal carotid artery were measured by electromagnetic flowmeter to calculate cerebral blood flow and cerebral vascular resistance. Results Total dextromethorphan dropping pills significantly increased cerebral blood flow in anesthetized dogs (P <0.05), and middle dose reduced cerebral vascular resistance (P <0.05, P <0.01). Conclusion Dragon Blood Total phenolic dripping pills to maintain blood perfusion of brain tissue has a significant role.