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躁狂症的常规治疗是采取碳酸锂单用或与精神抑制药联用。然而碳酸锂对部分难治性病人的效果较差,并且可能具有潜在的甲状腺和肾毒性。使用精神抑制药也并非全无风险。因此人们企图寻找毒副作用较少的药物来控制躁狂症状。近来报道的试验药物有降压药可乐定和抗心绞痛药异搏定。可乐定是一种α_2受体激动剂,能够减低去甲肾上腺素活性,因而可以用于阿片类戒断所引起的神经过敏症和恐慌焦虑病人。异搏定则属于
The usual treatment of mania is to take lithium carbonate alone or in combination with antipsychotics. Lithium carbonate, however, is less effective in some refractory patients and may have potential thyroid and nephrotoxicity. It is not without risk to use antipsychotics. Therefore, people are trying to find drugs with less toxic side effects to control manic symptoms. Recently reported test drugs are antihypertensive drug clonidine and anti-angina drug verapamil. Clonidine, an α 2 -receptor agonist, reduces norepinephrine activity and can be used in patients with neuroticism and panic-anxiety caused by opioid withdrawal. Verapamil belongs to