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长期糖皮质激素或环孢素A治疗的严重副作用,使儿童频繁复发、激素敏感型肾病综合征(frequently relapsing steroidsensitive nephrotic syndrome,FR-SSNS)的治疗变得复杂化。德国学者进行了一项随机、多中心、开放标签的交叉研究,比较霉酚酸酯(目标血浆霉酚酸谷底水平1.5~2.5μg/ml)和环孢素A(目标谷底水平80~100 ng/ml)治疗60例儿童FR-SSNS患者的效果和安全性。在治疗3和6个月时,以复发频率作为主要终点进行评价,并评估了药代动力学特性(曲线下面积,area under curve,
Long-term glucocorticoid or cyclosporin A treatment of serious side effects, frequent recurrence in children, hormone-sensitive nephrotic syndrome (frequent-relapsing steroid-sensitive nephrotic syndrome, FR-SSNS) treatment has become complicated. German scholars conducted a randomized, multicenter, open-label crossover study comparing mycophenolate mofetil (target plasma mycophenolic acid levels at the bottom of 1.5-2.5 μg / ml) and cyclosporine A (target trough levels of 80-100 ng / ml) in 60 children with FR-SSNS efficacy and safety. At 3 and 6 months of treatment, the frequency of recurrence was evaluated as the primary endpoint and the pharmacokinetic properties (area under curve, area under curve,