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目的：探讨银杏内酯 Ａ（Ｇｉｎｋｇｏｌｉｄｅ Ａ）对大鼠应激性溃疡发生的抑制作用及其可能机制。方法：Ｗｉｓｔａｒ大鼠，随机分成对照组和银杏内酯预处理组；以束缚水浸法建立应激性溃疡模型，通过胃窦部埋置电极记录应激状态下胃平滑肌自发电活动的变化，并测定血浆ＭＤＡ含量和ＳＯＤ活性以及观察胃粘膜的病理学改变。结果：银杏内酯Ａ５～２０ｍｇ／ｋｇ腹腔注射预处理组，应激所致的胃肌电活动紊乱和血浆 ＭＤＡ水平以及胃粘膜溃疡指数均明显低于对照组（Ｐ＜０．０５）；而血浆ＳＯＤ活性则高于对照（Ｐ＜０．０１），其效应具有剂量依赖性。结论：血小板活化因子拮抗剂银杏内酯Ａ能明显减轻束缚水浸应激引起的大鼠胃粘膜溃疡的发生，其机制可能是通过减少自由基产生和增加其清除，改善胃平滑肌动力障碍。
Objective: To investigate the inhibitory effect of Ginkgolide A on stress ulcers in rats and its possible mechanism. METHODS: Wistar rats were randomly divided into control group and ginkgo lactone pretreatment group. The stress ulcer model was established by irreducible water immersion method, and the change of gastric smooth muscle self-generating activity under stress was recorded through the antrum buried electrode. The plasma MDA content and SOD activity were measured and the pathological changes of gastric mucosa were observed. RESULTS: In the pretreatment group, the gastric myoelectric activity disorder, plasma MDA level, and gastric ulcer index were significantly lower in the pretreatment group than in the control group (P<0.05). Plasma SOD activity was higher than that of the control (P<0.01), and its effect was dose-dependent. CONCLUSION: Ginkgolide A, a platelet-activating factor antagonist, can significantly reduce the occurrence of gastric mucosal ulceration in rats induced by restraint water-soaked stress. The mechanism may be to reduce the generation of free radicals and increase their clearance and improve gastric smooth muscle dysmotility.