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目的探讨C-反应蛋白(CRP)、免疫球蛋白在强直性脊柱炎(AS)患者中的水平变化及其对AS的影响。方法采用免疫散射比浊法检测31例强直性脊柱炎患者与40例正常健康人血清中CRP、免疫球蛋白的水平进行比较。结果 CRP、IgA、IgG水平显著高于正常对照组(P<0.01),IgM水平与健康对照组无显著性差异(P>0.01)。结论 CRP、IgAIgG参与强直性脊柱炎的发病、发展过程,通过观察CRP、IgA、IgG的变化对强直性脊柱炎的病情活动性判断和疗效估计有重要意义。
Objective To investigate the level of C-reactive protein (CRP) and immunoglobulin in patients with ankylosing spondylitis (AS) and its effect on AS. Methods The serum levels of CRP and immunoglobulin in 31 patients with ankylosing spondylitis and 40 normal controls were compared by immunostaining turbidimetry. Results The levels of CRP, IgA and IgG were significantly higher than those in the normal control group (P <0.01). There was no significant difference in IgM levels between the two groups (P> 0.01). Conclusion CRP and IgAIgG are involved in the pathogenesis and progression of ankylosing spondylitis. It is of great significance to judge the activity of ankylosing spondylitis and evaluate the therapeutic effect by observing the changes of CRP, IgA and IgG.