脑梗死占急性脑梗死的20%~30%〔1,2〕。JAK2 V617F基因突变为体细胞获得性单核苷酸突变,是由JAK2基因1 849位鸟嘌呤(G)突变为胸腺嘧啶(T),使JAK2蛋白617位缬氨酸错义编码为苯丙氨酸,导致JH2区的空间结构发生变化,使其对JH1区的抑制作用消失、JAK2激酶的活性增加〔3〕。JAK2V617F基因突变可出现在非典型慢性粒细胞性白血病、慢性粒 Cerebral infarction accounts for 20% to 30% of acute cerebral infarction [1,2]. The JAK2 V617F gene mutation is a somatic acquired single nucleotide mutation, which is caused by the mutation of the guanine (G) at the position 849 to the thymine (J) of the JAK2 gene and the valine missense at the 617 position of the JAK2 protein as amphetamine Acid, resulting in changes in the spatial structure of JH2 area, so that the inhibition of JH1 area disappeared, JAK2 kinase activity increased 〔3〕. JAK2V617F gene mutations can occur in atypical chronic myelogenous leukemia, chronic