氯苯酚嗪(Clofazimine,摘者按:即B663,国内已试制成功)是一种酚嗪类衍化物,对分枝杆菌(特别是麻风杆菌)具有抗菌作用。此外,已经证实氯苯酚嗪对巨噬细胞的功能有促进作用,并能增强多形核白细胞的吞噬能力, 过去对坏疽性脓皮病的主要治疗方法是X线疗法及药物疗法(如水杨酸、磺胺吡啶、硫唑嘌呤和皮质类固醇,往往需要大剂量),而疗效难以肯定。本文报告了作者应用氯苯酚嗪治疗8例坏疽性脓皮病,男3例、女5例,年龄23～69岁。这些病例过去都曾用过抗菌素或水杨酸、磺胺吡啶、强的松龙、X线治疗,效果都不理想。此次口服氯苯酚嗪的 Chlorophenazine (Clofazimine, pick by: that B663, the domestic trial has been successful) is a phenazine derivatives, Mycobacterium (especially Leprosy) with antibacterial effect. In addition, it has been confirmed that chlorophenazine promotes the function of macrophages and enhances the phagocytic capacity of polymorphonuclear leukocytes. In the past, the main treatment for pyoderma gangrenosum was X-ray therapy and drug therapy (such as salicylic acid , Sulfapyridine, azathioprine and corticosteroids, often require large doses), and the efficacy is not sure. This article reports the authors use chlorophenazine treatment of pyoderma gangrenous 8 cases, 3 males and 5 females, aged 23 to 69 years. In the past these cases have used antibiotics or salicylic acid, sulfadiazine, prednisolone, X-ray treatment, the effect is not satisfactory. Oral chlorophenazine oral