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早在1917年Manasse就首次描述了胆固醇肉芽肿,但直到1956年Birrell重新提出注意这一特殊病变之前,本病一向被人们所忽略。甚至有经验的病理学家也常常将它与上皮样胆脂瘤相混淆。1929年Shambaugh报告二例蓝鼓膜征,经鼓膜切开和咽鼓管吹张治疗无效。此后,Fowler(1939),Odennell(1941),Kler(1948)相继报告新的病例。Odennell提出儿童蓝鼓膜和特发性血鼓室术语。Rager(1949)报告2例乳突皮质切除术,术中发现乳突气房内充满粘稠褐色液体,并详细描述了乳突内胆固醇肉芽肿的大体形态。Menck-Thyge-
As early as 1917 Manasse described cholesterol granuloma for the first time, but this disease was ignored until Birrell re-focused his attention on this particular lesion in 1956. Even experienced pathologists often confuse it with epithelioid cholesteatoma. Shambaugh in 1929 reported two cases of blue tympanic membrane signs, tympanotomy and eustachian tube blowing ineffective treatment. Since then, Fowler (1939), Odennell (1941), Kler (1948) have reported new cases. Odennell proposed the blue tympanic membrane and idiopathic hematology terms in children. Rager (1949) reported 2 cases of mastoid cystectomy, intraoperative mastoid gas was found filled with viscous brown liquid, and described in detail the general morphology of the granuloma within the mastoid. Menck-Thyge-