应用多元二次正交回归旋转组合设计试验，建立了毕节高海拔地区地膜玉米亩产量与密度、施肥诸因素相关的数学模型。提出了亩产４００ｋｇ以上和５００ｋｇ以上的栽培农艺方案。确如提高密度和增施磷肥是其中最关键的措施；并在密度、施肥种类、施肥方法（时期）等相互关系方面，获得了一些参数。 By using multivariate quadratic orthogonal regression and rotation combination design test, the mathematical model of mulberry yield and density and fertilizer application in high altitude area of ​​Bijie was established. Proposal per mu 400kg above and 500kg more than the cultivation of agronomic programs. Indeed, increasing density and increasing phosphorus were the most important measures. Some parameters were obtained in terms of density, types of fertilization and methods of fertilization (period).