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目的：探讨了支气管肺炎患儿治疗前后血清IGF-Ⅱ、IL-18和BNP水平的变化及临床意义。方法：应用放射免疫分析法、酶联法对39例支气管肺炎患者进行了治疗前后血清IGF-Ⅱ、IL-18和BNP检测，并于35名正常健康儿作比较。结果：支气管肺炎患儿在治疗前血清IGF-Ⅱ、IL-18和BNP水平均非常显著地高于正常人组（P＜0.01)，经治疗2周后则与正常儿比较无显著性差异（P＞0.05)。血清IGF-Ⅱ水平与IL-18、BNP水平呈正相关（r=0.49220.5184 P＜0.01）。结论：血清IGF-Ⅱ、IL-18和BNP以不同的方式参与了患儿的发病，其水平的检测对了解病情，指导临床治疗具有重要的临床价值。“,”objective:To explore the clinical significance and the changes of serum IGF-Ⅱ、IL-18 and BNP levels both before and after treatment in children with branchopneumonia .Methods:serum IGF-Ⅱ(withRIA),serumIL-18,BNP(withELISA) levels were determined both before and after treatment in 39 patients with children bronchopneumonia and compare with 35 patients in controls.Results:Before treatment,serum IGF-Ⅱ、IL-18 and BNP levels were significantly higher than those in controls (P0.05) Serum IGF-Ⅱ levels were positively correlated with serum IL-18 、BNP levels(r=0.4922 0.5184 P<0.01) Conclusion:serum IGF-Ⅱ IL-18 and BNP could take part in the pathogenesis of children bronchopneumonia in various ways and determination of these levels has great clinical value of understanding the il ness and guiding the clinical treatment.