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目的研究河北省卢龙县婴幼儿病毒性腹泻病原构成。方法 2010—2014年对卢龙县县医院所有<5岁住院腹泻儿童进行全年监测,对病毒性腹泻患儿收集流行病学信息和腹泻粪便采样进行病原学分析。结果共收集1 880份腹泻样本,4种病毒阳性样本1 356份,阳性率平均为72.1%,其中轮状病毒(HRV)占45.0%(846份),杯状病毒(HuCV)占18.3%(344份),腺病毒(Ade V)占6.3%(119份),星状病毒(AstV)占2.5%(47份)。1月—翌年12月为HRV发病高峰,1—3月为HuCV发病高峰,11月—翌年4月为Ade V发病高峰,2—3月为Astv发病高峰。HRV、HuCV、Astv均以12~月龄组病例最多,分别占38.1%、32.6%、38.2%,而Ade V的患儿以9~月龄组病例最多,占21.8%。轮状病毒G9血清型为流行毒株(57.1%),基因型P[8]为主(83.7%)。HuCV以GⅡ组为优势株。结论 HRV是婴幼儿腹泻主要病原。
Objective To study the pathogenic constitution of infantile viral diarrhea in Lulong County, Hebei Province. Methods From 2010 to 2014, all children aged <5 years hospitalized in Lulong County Hospital were monitored for the whole year. Epidemiological information and diarrhea stool samples collected from children with viral diarrhea were analyzed by etiology. Results A total of 1 880 samples of diarrhea were collected and 1 356 were positive for 4 viruses. The positive rate was 72.1%, of which 45.0% (846) were rotavirus (HRV) and 18.3% were Calicivirus (HuCV) 344), adenovirus (Ade V) accounted for 6.3% (119), and astrovirus (AstV) 2.5% (47). From January to December, the peak incidence of HRV is from January to March, the peak incidence of HuCV from January to March, the peak of Ade V from April to April next year and the peak of Astv from February to March. The cases of HRV, HuCV and Astv were the most in 12 ~ month group, accounting for 38.1%, 32.6% and 38.2% respectively, while those in AdeV group had the highest incidence in 9 ~ month group (21.8%). Rotavirus G9 serotypes were epidemic strains (57.1%) and genotype P [8] predominated (83.7%). HuCV G Ⅱ group as the dominant strain. Conclusion HRV is the main cause of infant diarrhea.