硝酸甘油作为一种血管舒张剂应用于心血管疾病治疗已有百余年历史,然而持续应用时,其扩张外周血管改善血流动力学的的效应就会迅速减弱甚至消失,即产生耐药,该现象大大限制了它的临床应用。近年来关于其耐药机制的研究有很大进展,特别是在ALDH2的活性降低、氧自由基的作用、内皮素的作用等方面。本文将对其进行介绍和讨论。 Nitroglycerin as a vasodilator used in the treatment of cardiovascular disease has a history of more than a hundred years, but continued application, its expansion of peripheral vascular hemodynamic effect will be rapidly reduced or even disappear, that is, drug resistance, This phenomenon greatly limits its clinical application. In recent years, great progress has been made on the research of its resistance mechanism, especially in the aspects of the activity of ALDH2, the function of oxygen free radicals and the function of endothelin. This article will be introduced and discussed.