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[目的]探讨磷脂酰胆碱(PC)对小鼠学习记忆过程三环节整合调节作用,为“PC是健脑食物”提供进一步实验室依据。[方法]设PC对小鼠记忆获得障碍、记忆巩固障碍、记忆再现障碍的改善作用3大组。每大组设4小组,包括模型对照组、磷脂酰胆碱3个剂量组(0.1g/kg.bw、0.2g/kg.bw、0.3g/kg.bw),每小组10只小鼠。实验期末对3大组分别进行跳台试验、避暗试验和水迷宫试验。[结果]记忆获得障碍实验中,学习试验时各剂量组的错误次数明显减少,消退试验时各剂量组的错误次数明显减少,潜伏期明显延长;记忆巩固障碍实验中,测验时各剂量组的潜伏期明显延长,消退试验时各剂量组的潜伏期明显延长、错误次数显著减少,0.3g/kg.bw组的错误动物百分率明显减少;记忆再现障碍实验中,消退试验时各剂量组的错误次数明显减少,且各剂量组到达终点的时间明显缩短。[结论]PC明显提高学习记忆过程三环节障碍小鼠的学习记忆能力,具有整合改善记忆效能的作用。
[Objective] To investigate the effect of phosphatidylcholine (PC) on the integration and regulation of three links in learning and memory of mice and provide further laboratory evidence for “PC is a brain-based food”. [Method] We set 3 groups of improving effect of PC on mice memory impairment, memory consolidation disorder and memory reproduction disorder. Each group consisted of 4 groups including model control group, 3 doses of phosphatidylcholine (0.1g / kg.bw, 0.2g / kg.bw, 0.3g / kg.bw), 10 mice per group. At the end of the experiment, the three groups were respectively subjected to jumping test, avoiding dark test and water maze test. [Results] During the memory impairment test, the number of errors in each dose group was significantly reduced during learning test. The number of errors in each dose group was significantly reduced and the incubation period was significantly prolonged in the regression test. In the memory consolidation disorder test, the latency of each dose group Significantly prolonged, regression test significantly increased the latency of each dose group, the number of errors significantly reduced, 0.3g / kg.bw group significantly reduced the percentage of false animals; memory reproduction disorder test, the regression test significantly reduced the number of errors in each dose group , And each dose group reached the end of the time significantly shorter. [Conclusion] PC significantly improves the learning and memory abilities of mice with tricyclic disorders during learning and memory, and has the effect of improving memory performance.