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目的探讨青春期女性乳腺叶状肿瘤与其他纤维上皮性肿瘤和青春期女性乳腺肥大的鉴别诊断。方法回顾分析13例11~20岁女性乳腺叶状肿瘤的病史及病理组织学特点,并复习相关文献。结果13例乳腺叶状肿瘤的肿瘤组织均表现异质性,即上皮间质比例差异及间质过度生长、腺体不规则扩张、上皮增生和分布异常,其为上皮和间质共同增生的结果。结论组织学异质性是叶状肿瘤的特点,临床有必要与细胞性纤维腺瘤、错构瘤及青春期女性乳腺肥大鉴别,因为这些乳腺病变的预后和临床处理方式不同。
Objective To investigate the differential diagnosis of adolescent female breast leaf tumor with other fibrous epithelial tumors and adolescent female breast hypertrophy. Methods Retrospective analysis of 13 cases of 11 to 20 years old female breast phyllodes tumor histopathology and histological features, and review the relevant literature. Results Thirteen breast phyllodes tumors showed heterogeneity in the tumor tissue, ie, differences in the proportion of epithelial mesenchyme and interstitial hyperplasia, irregular expansion of the glandular epithelium, epithelial hyperplasia and distribution, as a result of epithelial and interstitial co-hyperplasia . Conclusions Histological heterogeneity is the characteristic of phyllodes tumor. It is necessary to differentiate it from cellular fibroadenoma, hamartoma and adolescent mammary gland hypertrophy, because the prognosis and clinical treatment of these breast lesions are different.