支气管扩张的病理学定义是指永久性的支气管扩张。表现为慢性咳痰、反复加重,有时呈进行性肺部破坏。其发病机制尚不清楚,但新近有研究证实感染、炎症,酶成份之间的相互作用导致了气管支气管破坏的恶性循环。常见病原体如绿脓杆菌、肺炎链球菌、流感嗜血杆菌的致病作用也已受到重视 由于前炎症介质包括白介素-1、白介素-8、肿瘤坏死因子-α、白烯B_1的介导使扩张的支气管内中性粒细胞过多聚积活化的中性粒细胞释放弹性蛋白酶。在实验中可见该酶引起纤毛摆动减慢及气道粘膜破坏。因此该酶对支气管扩张的发病起了重要作用因为尚无金标准,所以有些学者提出了一些临床和实验室指标,包括肺量检查、痰量、发作频率和痰内前炎和介质的浓度但对于弹性蛋白酶与这些指标的关系知道很少,因此对这问题进行了 The pathological definition of bronchiectasis refers to permanent bronchiectasis. The performance of chronic sputum, repeatedly increased, and sometimes progressive pulmonary destruction. Its pathogenesis is not yet clear, but recent studies have confirmed that infection, inflammation, the interaction between the enzyme components lead to a vicious circle of tracheal bronchial destruction. The pathogenic effects of common pathogens such as Pseudomonas aeruginosa, Streptococcus pneumoniae and Haemophilus influenzae have also been taken seriously due to the mediation of proinflammatory mediators including interleukin-1, interleukin-8, tumor necrosis factor-alpha, and alkene B 1 In bronchial neutrophils, excessive accumulation of activated neutrophils releases elastase. In the experiment shows that the enzyme causes slow ciliary wobble and airway mucosal damage. Therefore, the enzyme plays an important role in the pathogenesis of bronchiectasis because there is no gold standard, so some scholars have put forward some clinical and laboratory indicators, including spirometry, sputum volume, seizure frequency and the concentration of pro-inflammatory and media but Little is known about the relationship between elastase and these indicators, so the question has been made