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目的:确定心率变异性(HRV)是否与机体炎症反应程度及冠状动脉粥样硬化程度有关。方法:受试者接受冠状动脉造影检查,采用Gensini评分系统反映冠状动脉病变的严重程度,通过24 h动态心电监测,采用时域分析法测定HRV,测定血清脂蛋白相关的磷脂酶A2(Lp-PLA2)、C-反应蛋白(CRP)、IL-6水平以反映机体炎症反应程度。结果:HRV较低的受试者具有较高的Gensini分值,HRV下降与炎症标志物水平升高相伴随。结论:HRV降低与炎症标志物水平及冠状动脉病变程度有关,说明植物神经功能障碍可能通过增强炎症反应促使冠状动脉硬化的发生。
OBJECTIVE: To determine if the heart rate variability (HRV) is related to the degree of inflammation and coronary atherosclerosis in the body. Methods: The subjects underwent coronary angiography. Gensini score system was used to reflect the severity of coronary artery disease. HRV was measured by 24 h Holter monitoring. The serum lipoprotein-associated phospholipase A2 (Lp -PLA2), C-reactive protein (CRP), IL-6 levels to reflect the degree of inflammatory response in the body. Results: Subjects with lower HRV had higher Gensini scores, and decreased HRV was associated with increased levels of inflammatory markers. Conclusion: The decrease of HRV is related to the level of inflammatory markers and the severity of coronary artery disease. It suggests that dysfunction of autonomic nerve may promote the development of coronary atherosclerosis by enhancing the inflammatory reaction.