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20例高血压患者按内生肌酐清除率（CLcr）、尿素氮（BUN）和肌酐（Cr）水平分为肾功能正常和受损两组，每组10例。均服地水硫■缓释片90mg，2／d，共7d。观察治疗前后血压、心率和肾功能变化，并用自动血压监测仪测量服药第7d的24h血压。结果：（1）该药能降低两组病人的收缩压和舒张压（P＜0．01），降压作用维持24h。（2）在肾功能受损组，该药能增加CLcr，ERPF，降低UMAE，BUN和Cr（P＜0．01）。因此地尔硫■缓释片不仅能有效地降低血压，而且能改善肾功能，适合高血压伴肾功能不全患者的治疗。缓释剂型能减少服药次数和减轻不良反应，提高降压治疗的顺应性。
According to the levels of endogenous creatinine clearance (CLcr), blood urea nitrogen (BUN) and creatinine (Cr), 20 patients with hypertension were divided into two groups, normal renal function and impaired group. Serve water sulfur ■ sustained release tablets 90mg, 2 / d, a total of 7d. The changes of blood pressure, heart rate and renal function were observed before and after treatment, and the blood pressure was measured by automatic blood pressure monitor on the 7th day. Results: (1) The drug can reduce the systolic and diastolic blood pressure in both groups (P <0.01), and maintain the hypotensive effect for 24h. (2) In the impaired renal function, the drug can increase CLcr, ERPF, reduce UMAE, BUN and Cr (P <0.01). Therefore diltiazem ■ sustained-release tablets can not only effectively reduce blood pressure, but also improve renal function, suitable for treatment of patients with hypertension and renal insufficiency. Sustained-release formulations can reduce the number of medication and reduce adverse reactions, improve the compliance of antihypertensive treatment.