探讨机械通气及纳洛酮对急性中毒所致呼吸衰竭的治疗效果。 3 0例立即经口气管内插管机械通气 ,同时给纳洛酮治疗 ,2 9例于 17h～ 12 0h顺利脱机拔管 ,死亡 1例。结果显示 ,纳洛酮能阻断呼吸衰竭时 β -内啡肽对呼吸的抑制 ,机械通气与纳洛酮配合治疗 ,可减少有创性机械通气 ,提高抢救成功率。 To investigate the effect of mechanical ventilation and naloxone on respiratory failure caused by acute poisoning. Thirty (30%) patients were treated with oral intubation immediately after mechanical ventilation while naloxone was given to them. Twenty-nine patients were successfully extubated from 17h to 120h and 1 patient died. The results showed that naloxone can block the respiration of β - endorphin in respiratory failure. Mechanical ventilation combined with naloxone can reduce the invasive mechanical ventilation and improve the success rate of rescue.