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目的观察鼻窦清合剂对兔鼻窦炎上颌窦黏膜炎症的影响。方法行窦口不完全堵塞加用金黄色葡萄球菌建立急慢性鼻窦炎动物模型后,予以鼻窦清合剂高、低剂量灌胃治疗,并设立空白组、模型组、鼻渊舒(鼻渊舒口服液灌胃)组作为对照;急性期用药1周,慢性期用药2周后,分别通过透射电子显微镜观察,比较各组兔上颌窦黏膜形态结构的变化。结果鼻窦清合剂低剂量组黏膜形态最接近正常组,且急性各组优于慢性各组。结论鼻窦清合剂可改善兔上颌窦炎症。
Objective To observe the effect of “Sinuqing Qingji” on inflammation of maxillary sinus mucosa in rabbit sinusitis. Methods After incomplete sinus ostium occlusion plus Staphylococcus aureus was established animal models of acute and chronic sinusitis, high and low doses of nasal debridement were given intragastrically, and a blank group, model group, Liquid gavage) group as a control; acute phase drug for 1 week, chronic drug treatment for 2 weeks, respectively, by transmission electron microscopy, to compare the morphological changes of rabbit mucosa in each group. Results Sinus Qing low dose group mucosal morphology closest to the normal group, and the acute group than the chronic group. Conclusion Sinomeniqing Mixture can improve rabbit maxillary sinus inflammation.