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目的探讨重症监护病房(ICU)洋葱伯克霍尔德菌肺部感染的临床特点及病原菌耐药情况及其防治措施。方法对2005年1月至2008年11月在ICU住院期间,28例洋葱伯克霍尔德菌院内肺部感染病例进行回顾性分析。结果本组病例多发生于老年人,有多种原发病或伴随疾病;感染患者往往病情突然加重,痰量明显增多,肺部渗出短期内明显增加;19种抗菌药物药敏试验结果显示复方磺胺甲基异噁唑、美罗培南、哌拉西林/他唑巴坦、头孢吡肟和头孢他啶的体外活性较高,在85%以上;其次为哌拉西林,敏感率为71.4%,头孢曲松、左氧沙星敏感率在50%~60%之间,环丙沙星敏感率为36%,其余均<30%。结论洋葱伯克霍尔德菌具有多重耐药性,治疗难度大,应引起足够重视,需根据药敏试验结果选用敏感药物,如美罗培南、复方磺胺甲基异噁唑、哌拉西林/他唑巴坦、头孢他啶和头孢吡肟等。
Objective To investigate the clinical features and pathogens resistance of Burkholderia cepacia oncology in Intensive Care Unit (ICU) and the preventive measures. Methods A retrospective analysis of 28 cases of Burkholderia cepacia inpatients with lung infections during hospital stay in ICU from January 2005 to November 2008 was performed. Results This group of patients occurred in the elderly, there are a variety of primary disease or concomitant disease; patients with infections are often aggravated suddenly, sputum volume increased significantly increased pulmonary effusion in the short term; drug susceptibility test results of 19 kinds of antibiotics The in vitro activity of compound sulfamethoxazole, meropenem, piperacillin / tazobactam, cefepime and ceftazidime was higher than 85%, followed by piperacillin, the sensitivity was 71.4% Sensitivity of levofloxacin was between 50% and 60%, sensitivity of ciprofloxacin was 36%, and the others were all less than 30%. Conclusion Burkholderia cepacia has multi-drug resistance, which is difficult to treat and should be taken seriously. Sensitive drugs such as meropenem, compound sulfamethoxazole and piperacillin / Zolbactam, ceftazidime and cefepime and so on.