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目的探讨血清胱抑素C(cystatin C)浓度与颈动脉粥样硬化的关系。方法选择2012年1月至2014年1月在成都医学院第一附属医院心内科住院的患者1 263例,检测其血清胱抑素C、血脂、血糖等血液生化指标,彩色多普勒超声评价颈动脉内膜中层厚度(inteima-media thickness,IMT)及粥样硬化斑块的情况。根据彩色多普勒超声结果将研究人群分为颈动脉粥样硬化组(IMT≥0.9 mm,伴或不伴有斑块形成)及颈动脉内膜正常组,用t检验分析两组患者血清胱抑素C、血脂、血糖等指标的差异。Spearman相关分析、Logistic回归分析血清胱抑素C与颈动脉粥样硬化的关系。结果 1 263例患者的年龄为(65.2±8.5)岁,男性共439例(34.8%)。颈动脉粥样硬化患者的血清胱抑素C浓度高于颈动脉内膜正常组,差异有统计学意义[(1.16±0.16)mg/L vs.(0.96±0.41)mg/L,P<0.001]。相关分析结果显示,血清胱抑素C与颈动脉粥样硬化呈正相关(r=0.293,P<0.001)。多因素Logistic回归分析校正性别、年龄等因素后,血清胱抑素C与颈动脉粥样硬化独立相关(OR=2.682,95%CI:1.682~4.277,P<0.001)。结论血清胱抑素C浓度与颈动脉粥样硬化相关,血清胱抑素C可能是颈动脉粥样硬化的独立危险因素之一。
Objective To investigate the relationship between serum cystatin C and carotid atherosclerosis. Methods A total of 1 263 inpatients admitted to the First Affiliated Hospital of Chengdu Medical College from January 2012 to January 2014 were enrolled in this study. Serum levels of cystatin C, lipids, blood glucose and other blood biochemical parameters were measured. Color Doppler echocardiography Carotid artery intima-media thickness (IMT) and atherosclerotic plaques. The study population was divided into carotid atherosclerosis group (IMT≥0.9 mm, with or without plaque formation) and carotid intima-normal group according to the results of color Doppler ultrasound. The t-test was used to analyze the serum cyst Sugan C, lipids, blood glucose and other indicators of the difference. Spearman correlation analysis, Logistic regression analysis of the relationship between serum cystatin C and carotid atherosclerosis. Results A total of 1 263 patients were (65.2 ± 8.5) years old and 439 (34.8%) were male. Serum levels of cystatin C in patients with carotid atherosclerosis were significantly higher than those in carotid intima normal group [(1.16 ± 0.16) mg / L vs. (0.96 ± 0.41) mg / L, P <0.001 ]. Correlation analysis showed that serum cystatin C was positively correlated with carotid atherosclerosis (r = 0.293, P <0.001). Multivariate logistic regression analysis showed that serum cystatin C was independently associated with carotid atherosclerosis (OR = 2.682, 95% CI: 1.682-4.277, P <0.001) after adjusting for gender and age. Conclusions Serum levels of cystatin C are associated with carotid atherosclerosis. Serum cystatin C may be an independent risk factor for carotid atherosclerosis.