采用免疫组织化学技术,辅以透射电镜及普通病理学观察,研究不同时期的日本血吸虫病兔肝内血管壁免疫球蛋白和补体的变化。结果:发现虫卵肉芽肿周围、肝窦壁和门管区门静脉壁有IgG、IgE、C3和C4沉着。伴门管区纤维化、门静脉分支管壁纤维化和肝窦壁毛细血管化。电镜观察发现,肝窦内有浆细胞聚积,窦内皮细胞受损。表明有免疫复合物介导的损伤,导致肝微循环障碍,并继发肝纤维化和门静脉高压症。 Immunohistochemical techniques, supplemented by transmission electron microscopy and routine pathological observation of different stages of schistosomiasis Japan hepatic vascular wall immunoglobulin and complement changes. Results: There were IgG, IgE, C3 and C4 in the portal vein wall of hepatic sinusoid and portal area around the ova granuloma. With portal fibrosis, portal vein branch wall fibrosis and hepatic sinusoidal capillary. Electron microscopy showed that within the sinusoidal plasma cells accumulate, sinus endothelial cell damage. Indicating immune-mediated damage, leading to hepatic microcirculation and secondary hepatic fibrosis and portal hypertension.