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用核酸序列分析技术，测定１例乙型肝炎表面抗原（ＨＢｓＡｇ）阴性中国人感染的乙型肝炎病毒ＨＢＶ／ａｄｗ亚型全基因组序列。该变异株全序列为３２２４个碱基，与从同一地区２例ＨＢｓＡｇ阳性携带者得到的ａｄｗ和ａｄｒ全序列的同源性分别为９８．０％和９２．５％，与已出版的Ａ—Ｅ基因组比较，进行了病毒的系统树分析。该变异毒株除在外膜基因Ａ决定簇前有９个碱基插入外，在多种调控元件，包括启动子ＳＰＩ、ＳＰＩＩ、ＣＰ、ＸＰ、增强子ＥＮＩ和ＥＮＩＩ，均无独特的变异点。
One nucleotide sequence of hepatitis B virus (HBV) / adw subtype of hepatitis B surface antigen (HBsAg) negative Chinese was detected by nucleic acid sequence analysis. The full-length variant of this variant was 3224 bases, which shared 98.0% and 92.5% identity with the full-length sequences of adw and adr from two HBsAg positive carriers in the same area respectively. Compared with the published A- E genome, a systematic phylogenetic analysis of the virus was performed. The mutant had no unique mutation in many regulatory elements including promoter SPI, SPII, CP, XP, enhancers ENI and ENII, except for a 9 base insertion in front of the outer membrane A determinant.