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目的:观察静脉注射人血丙种球蛋白(IVIG)治疗特发性血小板减少性紫癜(ITP)的疗效。方法:36例ITP住院患儿随机分成IVIG治疗组,静滴IVIG320～500mg/kg·d连续应用3～5天;强的松对照组,口服强的松1～2.5mg/kg·d,治疗四周。结果IVIG治疗ITP有明显疗效,治疗前后比较有显著性差异(P<0.01),与强的松疗效比较无显著性差异(P>0.05),但升高血小板数的时间比强的松明显缩短(P<0.01)。结论:IVIG治疗ITP疗效显著,具有快速升高血小板数、改善出血症状、保护重要脏器免于出血的独特作用,不良反应少,是小儿重症及特殊ITP患儿治疗较理想的药物。
Objective: To observe the effect of intravenous injection of human blood gamma globulin (IVIG) on idiopathic thrombocytopenic purpura (ITP). Methods: Thirty-six ITP hospitalized children were randomly divided into IVIG treatment group, intravenous IVIG320 ~ 500mg / kg · d for 3 to 5 days continuously; prednisone control group, oral prednisone 1 ~ 2.5mg / kg · d, treatment Around. Results IVIG treatment of ITP significant effect, before and after treatment were significantly different (P <0.01), and no significant difference compared with the efficacy of prednisone (P> 0.05), but increased platelet number than prednisone was significantly shorter (P <0.01). Conclusion: IVIG treatment of ITP significant effect, with rapid increase in platelet count, improve bleeding symptoms, protect the vital organs from bleeding, the unique role of fewer adverse reactions, is an ideal treatment for children with severe ITP and special drugs.