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前言本文介绍了许多有化疗价值的驱蠕剂和抗寄生虫药物。这些药物是苯、呋喃、噻吩、噻唑、咪唑以及多环芳香族等的硝基化合物。探讨其治疗效果和构效关系,设计更有效的药物,用于治疗人体主要寄生虫病——血吸虫病、丝虫病和锥虫病。硝基芳香族和硝基杂环类抗寄生虫药物1.硝基苯类:硝基苯类有驱蠕作用且结构最简单的是取代苯酚类化合物。Thorson 等发现二氯硝酚对家畜有显著的驱蠕作用。二碘硝酚有驱
Preface This article describes a number of anti-infectives and anti-parasite drugs that have chemotherapeutic benefits. These drugs are benzene, furan, thiophene, thiazole, imidazole and polycyclic aromatic nitro compounds. Explore its therapeutic effect and structure-activity relationship, design more effective drugs for the treatment of major human parasitic diseases - schistosomiasis, filariasis and trypanosomiasis. Nitroaromatic and nitro-heterocyclic anti-parasitic drugs 1. Nitrobenzenes: Nitrobenzene has the role of anti-creep and the simplest structure is to replace the phenolic compounds. Thorson et al. Found that dinitrophenol has a significant anti-microbial effect on livestock. Dinitrophenol has flooding