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目的研究Ⅲ型狼疮性肾炎患者血清中细胞因子IL-10的表达。方法应用ELISA方法检测60例各型Ⅲ型狼疮性肾炎患者和30例正常对照组患者血清中IL-10的表达水平。结果血清中IL-10水平在Ⅲ(A)组、Ⅲ(A/C)组和Ⅲ(C)组患者中依次降低,三种类型的Ⅲ型狼疮性肾炎患者血清中的IL-10之间有显著性差异。结论Ⅲ型狼疮性肾炎中活动性病变患者IL-10表达增加,在Ⅲ型狼疮性肾炎的发生和发展中起重要作用。
Objective To study the expression of IL-10 in serum of patients with type Ⅲ lupus nephritis. Methods The serum levels of IL-10 in 60 patients with type Ⅲ lupus nephritis and 30 normal controls were detected by ELISA. Results Serum levels of IL-10 decreased in turn in patients of group Ⅲ (A), group Ⅲ (A / C), and group Ⅲ (C). IL-10 levels in sera of three types of patients with type Ⅲ lupus nephritis There are significant differences. Conclusion The expression of IL-10 is increased in active disease of type Ⅲ lupus nephritis, and plays an important role in the occurrence and development of type Ⅲ lupus nephritis.